Yasuyuki Ohkawa

1.Kajitani T, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Kimura H, Ohkawa Y, Obuse C, Hermand D, Murakami Y
Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.
PNAS., 2017 Dec 26;114(52):E11208-E11217. doi: 10.1073/pnas.1714579115. Epub 2017 Dec 13.
Pubmed ID: 29237752  [領域内共同研究:平岡、木村、大川、小布施]
2. Kudou K, Komatsu T, Nogami J, Maehara K, Harada A, Saeki H, Oki E, Maehara Y, Ohkawa Y.
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Open Biol. , 2017
Pubmed ID: 28878038
3.Semba Y, Harada A, Maehara K, Oki S; Meno C, Ueda J, Yamagata K, Suzuki A, Onimaru, M, Nogami J, Okada S, Akashi K, Ohkawa Y.
Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells.
Nucleic Acids Res., 2017
Pubmed ID: 28549158
4.Kato D, Osakabe A, Arimura Y, Mizukami Y, Horikoshi N, Saikusa K, Akashi S, Nishimura Y, Park SY, Nogami J, Maehara K, Ohkawa Y, Matsumoto A, Kono H, Inoue R , Sugiyama M, Kurumizaka H.
Crystal structure of the overlapping dinucleosome composed of hexasome and octasome.
Science., 2017
Pubmed ID: 28408607
5.Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Yoshizaki S, Harimaya K, Nakashima Y, Okada S.
Interaction of reactive astrocytes with collagen type I induces astrocytic scar formation through the integrin/N-cadherin pathway after spinal cord injury.
Nat Med., 2017
In press
6.Li B, Baba T, Miyabayashi K, Sato T, Shima Y, Ichinose T, Miura D, Ohkawa Y, Suyama M, Morohashi KI.
Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1cells.
Endocr J., 2017
Pubmed ID: 28202838
7.Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanai Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI.
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.
Sci Rep., 2017
Pubmed ID: 28150810
8.Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.
Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Cell Rep., 2017
Pubmed ID: 28099840
9.Yokota K, Kobayakawa K, Saito T, Hara M, Kijima K, Ohkawa Y, Harada A, Okazaki K, Ishihara K, Yoshida S, Kudo A, Iwamoto Y, Okada S.
Periostin Promotes Scar Formation through the Interaction between Pericytes and InfiltratingMonocytes/Macrophages after Spinal Cord Injury.
Am J Pathol., 2017
Pubmed ID: 28082119
10.Miyabayashi K, Shima Y, Inoue M, Sato T, Baba T, Ohkawa Y, Suyama M, Morohashi KI.
Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development.
Sex Dev., 2016
Pubmed ID: 27960177
11.Kujirai T, Horikoshi N, Sato K, Maehara K, Machida S, Osakabe A, Kimura H, Ohkawa Y, Kurumizaka H.
Structure and function of human histone H3.Y nucleosome.
Nucleic Acids Res., 2016
Pubmed ID: 27016736
12.Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T , Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N; Eurogout Consortium, Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H.
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include uratetransporter genes.
Ann Rheum Dis., 2016
Pubmed ID: 27899376
13.Sawano S, Komiya Y, Ichitsubo R, Ohkawa Y, Nakamura M, Tatsumi R, Ikeuchi Y, Mizunoya W.
A One-Step Immunostaining Method to Visualize Rodent Muscle Fiber Type within a Single Specimen.
PLoS One., 2016
Pubmed ID: 27814384
14.Kuniyoshi Y, Maehara K, Iwasaki T, Hayashi M, Semba Y, Fujita M, Sato Y, Kimura H, Harada A, Ohkawa Y.
Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas.
PLoS One., 2016
Pubmed ID: 27788226
15.Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI.
CHD8 haploinsufficiency results inautistic-like phenotypes in mice.
Nature., 2016
Pubmed ID: 27602517
16.Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MM.
MRG15 is required for pre-mRNA splicing and spermatogenesis.
Proc Natl Acad Sci U S A. , 2016
Pubmed ID: 27573846
17.Torigata K, Daisuke O, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S,Ohkawa Y, Yabuta N, Kondo Y, Nojima H.
LATS2 Positively Regulates Polycomb Repressive Complex 2.
PLoS One., 2016
Pubmed ID: 27434182
18.Yabe-Wada T, Matsuba S, Takeda K, Sato T, Suyama M, Ohkawa Y, Takai T, Shi H, Philpott CC, Nakamura A.
TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin.
Sci Rep., 2016
Pubmed ID: 27220277
19.Yokota K, Saito T, Kobayakawa K, Kubota K, Hara M, Murata M, Ohkawa Y, Iwamoto Y, Okada S.
The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury.
Sci Rep., 2016
Pubmed ID: 27156468
20.Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y.
Histone H4 lysine 20 acetylation is associated with gene repression in human cells.
Sci Rep., 2016
Pubmed ID: 27064113
21.Kobayashi W, Takaku M, Machida S, Tachiwana H, Maehara K, Ohkawa Y, Kurumizaka H.
Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.
Sci Rep., 2016
Pubmed ID: 27052786
22.Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.
J Cell Biochem., 2016
Pubmed ID: 26359639
23.Tanaka M, Shiota M, Nakao T, Uemura R, Nishi S, Ohkawa Y, Matsumoto M, Yamaguchi M, Osada-Oka M, Inagaki A, Takahashi K, Nakayama KI, Gi M, Izumi Y, Miura K, Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J Proteomics., 2016
Pubmed ID: 26780229
24. Urahama, T., Harada, A., Maehara, K., Horikoshi, N., Sato, K., Sato, Y., Shiraishi, K., Sugino, N., Osakabe, A., Tachiwana, H., Kagawa, W., Kimura, H., Ohkawa, Y., and Kurumizaka, H.
Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis
Epigenetics & Chromatin, 2016
(web: http://www.epigeneticsandchromatin.com/content/9/1/2)
25. Oka, M.*, Mura, S., Yamada, K., Sangel, P., Hirata, S., Maehara, K., Kawakami, K., Tachibana, T., Ohkawa, Y., Kimura, H., and Yoneda, Y.*
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes
Elife 5, 2016
Pubmed ID: 26740045
26. Osakabe, A., Adachi, F., Arimura, Y., Maehara, K., Ohkawa, Y., and Kurumizaka, H.
Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA
Open Biol 5, 2015
Pubmed ID: 26446621
27. Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H., and Ohkawa, Y.
Tissue-specific expression of histone H3 variants diversified after species separation
Epigenetics Chromatin 8, 35, 2015
Pubmed ID: 26388943
28. Hayashi, M., Maehara, K., Harada, A., Semba, Y., Kudo, K., Takahashi, H., Oki, S., Meno, C., Ichiyanagi, K., Akashi, K., and Ohkawa, Y.
Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2
J Cell Biochem, 2015
Pubmed ID: 26359639
29. Shimaji, K., Konishi, T., Tanaka, S., Yoshida, H., Kato, Y., Ohkawa, Y., Sato, T., Suyama, M., Kimura, H., and Yamaguchi, M.
Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis
Genes Cells, 2015
Pubmed ID: 26334932
30. Yokota, K., Kobayakawa, K., Kubota, K., Miyawaki, A., Okano, H., Ohkawa, Y., Iwamoto, Y., and Okada, S.
Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury
Stem Cell Reports 5, 264-277, 2015
Pubmed ID: 26190527
31. Nasipak, B. T., Padilla-Benavides, T., Green, K. M., Leszyk, J. D., Mao, W., Konda, S., Sif, S., Shaffer, S. A., Ohkawa, Y., and Imbalzano, A. N.
Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme
Nat Commun 6, 7441, 2015
Pubmed ID: 26081415
32. Nishimura, T., Sato, T., Yamamoto, Y., Watakabe, I., Ohkawa, Y., Suyama, M., Kobayashi, S., and Tanaka, M.
Sex determination. foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka
Science 349, 328-331, 2015
Pubmed ID: 26067255
33. Ohnishi, Y. H., Ohnishi, Y. N., Nakamura, T., Ohno, M., Kennedy, P. J., Ohkawa, Y., Nishi, A., Neve, R., Tsuzuki, T., and Nestler, E. J.
PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens
PLoS One 10, e0126710, 2015
Pubmed ID: 25962134
34. Hayashi-Takanaka, Y., Maehara, K., Harada, A., Umehara, T., Yokoyama, S., Obuse, C., Ohkawa, Y., Nozaki, N., and Kimura, H.
Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies
Chromosome Res ,2015
(web: http://link.springer.com/article/10.1007/s10577-015-9486-4 )
35. Tomita, S., Abdalla, M. O. A., Fujiwara, S., Matsumori, H., Maehara, K., Ohkawa, Y., Iwase, H., Saitoh, N., and Nakao, M.
A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation
Nat Commun 6, 6966, 2015
Pubmed ID: 25923108
36. Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C. W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J. W., Conaway, R. C., and Hatakeyama, S.
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex
Nat Commun 6, 5941, 2015
Pubmed ID: 25575120
37. Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y., and Fujita, M.
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture
Nucleic Acids Res, Jul 13;43(12):5898-911, 2015
Pubmed ID: 25990725
38. Nakamura, M., Shibata, K., Hatano, S., Sato, T., Ohkawa, Y., Yamada, H., Ikuta, K., and Yoshikai, Y.
A genome-wide analysis identifies a notch-RBP-Jkappa-IL-7Ralpha axis that controls IL-17-producing gammadelta T cell homeostasis in mice
J Immunol 194, 243-251, 2015
Pubmed ID: 25429074
39. Maehara, K., and Ohkawa, Y.
agplus: a rapid and flexible tool for aggregation plots
Bioinformatics, 2015
Pubmed ID: 25995229
40. Kawaguchi, T., Tanigawa, A., Naganuma, T., Ohkawa, Y., Souquere, S., Pierron, G., and Hirose, T.
SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies
Proc Natl Acad Sci U S A 112, 4304-4309, 2015
Pubmed ID: 25831520
41. Harada, A., Mallappa, C., Okada, S., Butler, J. T., Baker, S. P., Lawrence, J. B., Ohkawa, Y., and Imbalzano, A. N.
Spatial re-organization of myogenic regulatory sequences temporally controls gene expression
Nucleic Acids Res 43, 2008-2021, 2015
Pubmed ID: 25653159
42. Harada, A., Maehara, K., Sato, Y., Konno, D., Tachibana, T., Kimura, H., and Ohkawa, Y.
Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle
Nucleic Acids Res 43, 775-786, 2015
Pubmed ID: 25539924
43. Yokoyama, A., Igarashi, K., Sato, T., Takagi, K., Otsuka I, M., Shishido, Y., Baba, T., Ito, R., Kanno, J., Ohkawa, Y., Morohashi, K.-I., and Sugawara, A.
Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex
J Biol Chem 289, 18152-18162, 2014
Pubmed ID: 24828497
44. Ueda, J., Maehara, K., Mashiko, D., Ichinose, T., Yao, T., Hori, M., Sato, Y., Kimura, H., Ohkawa, Y., and Yamagata, K.
Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO
Stem Cell Reports 2, 910-924, 2014
Pubmed ID: 24936475
45. Tanaka, M., Yamaguchi, M., Shiota, M., Kawamoto, Y., Takahashi, K., Inagaki, A., Osada-Oka, M., Harada, A., Wanibuchi, H., Izumi, Y., Miura, K., Iwao, H., and Ohkawa, Y.
Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2
Monoclon Antib Immunodiagn Immunother 33, 261-269, 2014
Pubmed ID: 25171006
46. Tanaka, M., Mun, S., Harada, A., Ohkawa, Y., Inagaki, A., Sano, S., Takahashi, K., Izumi, Y., Osada-Oka, M., Wanibuchi, H., Yamagata, M., Yukimura, T., Miura, K., Shiota, M., and Iwao, H.
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions
PLoS One 9, e96785, 2014
Pubmed ID: 24801886
47. Tamura, I., Ohkawa, Y., Sato, T., Suyama, M., Jozaki, K., Okada, M., Lee, L., Maekawa, R., Asada, H., Sato, S., Yamagata, Y., Tamura, H., and Sugino, N.
Genome-wide analysis of histone modifications in human endometrial stromal cells
Mol Endocrinol 28, 1656-1669, 2014
Pubmed ID: 25073104
48. SStasevich, T. J., Hayashi-Takanaka, Y., Sato, Y., Maehara, K., Ohkawa, Y., Sakata-Sogawa, K., Tokunaga, M., Nagase, T., Nozaki, N., McNally, J. G., and Kimura, H.
Regulation of RNA polymerase II activation by histone acetylation in single living cells
Nature 516, 272-275, 2014
Pubmed ID: 25252976
49. Oki, S., Maehara, K., Ohkawa, Y., and Meno, C.
SraTailor: graphical user interface software for processing and visualizing ChIP-seq data
Genes Cells 19, 919-926, 2014
Pubmed ID: 25324176
50. Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.
Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation
Immunity 41, 1040-1051, 2014
Pubmed ID: 25484301
51. LeBlanc, S. E., Wu, Q., Barutcu, A. R., Xiao, H., Ohkawa, Y., and Imbalzano, A. N.
The PPARgamma locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner
PLoS One 9, e86140, 2014
Pubmed ID: 24465921
52. Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y., and Okada, S.
Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans
Sci Transl Med 6, 256ra137, 2014
Pubmed ID: 25273098
53. Harada, A., Okazaki, E., Okada, S., Tachibana, T., and Ohkawa, Y.
Production of a monoclonal antibody for C/EBPbeta: the subnuclear localization of C/EBPbeta in mouse L929 cells
Monoclon Antib Immunodiagn Immunother 33, 34-37, 2014
Pubmed ID: 24555934
54. Harada, A., Hayashi, M., Kuniyoshi, Y., Semba, Y., Sugahara, S., Tachibana, T., Ohkawa, Y., and Fujita, M.
Generation of a monoclonal antibody for INI1/hSNF5/BAF47
Monoclon Antib Immunodiagn Immunother 33, 49-51, 2014
Pubmed ID: 24555937
55. Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C.-Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B.-C., and Morohashi, K.-I.
Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1
Nat Commun 5, 3634, 2014
Pubmed ID: 24727981
56. Kitajima, K., Oki, S., Ohkawa, Y., Sumi, T., and Meno, C.
Wnt signaling regulates left-right axis formation in the node of mouse embryos
Dev Biol 380, 222-232, 2013
Pubmed ID: 23707899
57. Katahira, J., Okuzaki, D., Inoue, H., Yoneda, Y., Maehara, K., and Ohkawa, Y.
Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I
Nucleic Acids Res 41, 7060-7072, 2013
Pubmed ID: 23685434

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