木村 宏

発表論文(平成28年度)

1. Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H.
A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.
J Mol Biol. , 2016
Pubmed ID: 27534817  
 [領域内共同研究:木村・浅川・原口・山縣・上田・平岡・胡桃坂]
2. Kaimori, JY., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H., Isaka, Y.
Histone H4 lysine 20 acetylation is associated with gene repression in human cells.
Sci Rep. , 2016
Pubmed ID: 27064113  
 [領域内共同研究:木村・大川・小布施]

発表論文(平成25年度~平成27年度)

1. Suzuki, S., Kato, H., Suzuki, Y., Chikashige, Y., Hiraoka, Y., Kimura, H., Nagao, K., Obuse, C., Takahata, S., and Murakami, Y.
Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast
Nucleic Acids Res, 2016
Pubmed ID: 26792892
[領域内共同研究:平岡・木村・小布施]
2. Urahama, T., Harada, A., Maehara, K., Horikoshi, N., Sato, K., Sato, Y., Shiraishi, K., Sugino, N., Osakabe, A., Tachiwana, H., Kagawa, W., Kimura, H., Ohkawa, Y., and Kurumizaka, H.
Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis
Epigenetics & Chromatin, 2016
(web: http://www.epigeneticsandchromatin.com/content/9/1/2)
 [領域内共同研究:香川・木村・大川・胡桃坂]
3. Oka, M.*, Mura, S., Yamada, K., Sangel, P., Hirata, S., Maehara, K., Kawakami, K., Tachibana, T., Ohkawa, Y., Kimura, H., and Yoneda, Y.*
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes
Elife 5, 2016
Pubmed ID: 26740045
 [領域内共同研究:岡・大川・木村・米田]
4. Dias, J. D., Rito, T., Torlai Triglia, E., Kukalev, A., Ferrai, C., Chotalia, M., Brookes, E., Kimura, H., and Pombo, A.
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells
Elife 4, 2015
Pubmed ID: 26687004 責任著者
5. Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H., and Ohkawa, Y.
Tissue-specific expression of histone H3 variants diversified after species separation
Epigenetics Chromatin 8, 35, 2015
Pubmed ID: 26388943
 [領域内共同研究:木村・大川]
6. Shimaji, K., Konishi, T., Tanaka, S., Yoshida, H., Kato, Y., Ohkawa, Y., Sato, T., Suyama, M., Kimura, H., and Yamaguchi, M.
Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis
Genes Cells, 2015
Pubmed ID: 26334932
 [領域内共同研究:大川・木村]
7. Hayashi-Takanaka, Y., Maehara, K., Harada, A., Umehara, T., Yokoyama, S., Obuse, C., Ohkawa, Y., Nozaki, N., and Kimura, H.
Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies
Chromosome Res ,2015
(web: http://link.springer.com/article/10.1007/s10577-015-9486-4 ) 責任著者
 [領域内共同研究:小布施・大川・木村]
8. Kimura, H., Hayashi-Takanaka, Y., Stasevich, T. J., and Sato, Y.
Visualizing posttranslational and epigenetic modifications of endogenous proteins in vivo
Histochem Cell Biol 144, 101-109, 2015
Pubmed ID:26138929 筆頭著者
9. Ruan, K., Yamamoto, T. G., Asakawa, H., Chikashige, Y., Kimura, H., Masukata, H., Haraguchi, T., and Hiraoka, Y.
Histone H4 acetylation required for chromatin decompaction during DNA replication
Sci Rep 5, 12720, 2015
Pubmed ID: 4520004
 [領域内共同研究:淺川・木村・原口・平岡]
10. Matsuda, A., Chikashige, Y., Ding, D. Q., Ohtsuki, C., Mori, C., Asakawa, H., Kimura, H., Haraguchi, T., and Hiraoka, Y.
Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast
Nat Commun 6, 7753, 2015
Pubmed ID: 26205977
 [領域内共同研究:淺川・木村・原口・平岡]
11. Nakatani, T., Yamagata, K., Kimura, T., Oda, M., Nakashima, H., Hori, M., Sekita, Y., Arakawa, T., Nakamura, T., and Nakano, T.
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced gammaH2AX accumulation
EMBO Rep 16, 582-589, 2015
Pubmed ID: 25694116
12. Mukai, M., Hira, S., Nakamura, K., Nakamura, S., Kimura, H., Sato, M., and Kobayashi, S.
H3K36 Trimethylation-Mediated Epigenetic Regulation is Activated by Bam and Promotes Germ Cell Differentiation During Early Oogenesis in Drosophila
Biol Open 4, 119-124, 2015
Pubmed ID: 25572421
13. Kirschner, K., Samarajiwa, S. A., Cairns, J. M., Menon, S., Perez-Mancera, P. A., Tomimatsu, K., Bermejo-Rodriguez, C., Ito, Y., Chandra, T., Narita, M., Lyons, S. K., Lynch, A. G., Kimura, H., Ohbayashi, T., Tavare, S., and Narita, M.
Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
PLoS Genet 11, e1005053, 2015
Pubmed ID: 25790137
14. Kamiunten, T., Ideno, H., Shimada, A., Nakamura, Y., Kimura, H., Nakashima, K., and Nifuji, A.
Coordinated expression of H3K9 histone methyltransferases during tooth development in mice
Histochem Cell Biol 143, 259-266, 2015
Pubmed ID: 25294562
15. Iwamoto, D., Yamagata, K., Kishi, M., Hayashi-Takanaka, Y., Kimura, H., Wakayama, T., and Saeki, K.
Early development of cloned bovine embryos produced from oocytes enucleated by fluorescence metaphase II imaging using a conventional halogen-lamp microscope
Cell Reprogram 17, 106-114, 2015
Pubmed ID: 25826723
16. Harada, A., Maehara, K., Sato, Y., Konno, D., Tachibana, T., Kimura, H., and Ohkawa, Y.
Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle
Nucleic Acids Res 43, 775-786, 2015
Pubmed ID: 25539924
 [領域内共同研究:大川・木村]
17. Zierhut, C., Jenness, C., Kimura, H., and Funabiki, H.
Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion
Nat Struct Mol Biol 21, 617-625, 2014
Pubmed ID: 24952593
18. Yokoyama, Y., Matsumoto, A., Hieda, M., Shinchi, Y., Ogihara, E., Hamada, M., Nishioka, Y., Kimura, H., Yoshidome, K., Tsujimoto, M., and Matsuura, N.
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity
Breast Cancer Res 16, R66, 2014
Pubmed ID: 24953066
19. Stasevich, T. J., Sato, Y., Nozaki, N., and Kimura, H.
Quantifying histone and RNA polymerase II post-translational modification dynamics in mother and daughter cells
Methods 70, 77-88, 2014
Pubmed ID: 25131722 責任著者
20. Stasevich, T. J., Hayashi-Takanaka, Y., Sato, Y., Maehara, K., Ohkawa, Y., Sakata-Sogawa, K., Tokunaga, M., Nagase, T., Nozaki, N., McNally, J. G., and Kimura, H.
Regulation of RNA polymerase II activation by histone acetylation in single living cells
Nature 516, 272-275, 2014
Pubmed ID: 25252976 責任著者
 [領域内共同研究:木村・徳永・大川]
21. Song, C., Feodorova, Y., Guy, J., Peichl, L., Jost, K. L., Kimura, H., Cardoso, M. C., Bird, A., Leonhardt, H., Joffe, B., and Solovei, I.
DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution
Epigenetics Chromatin 7, 17, 2014
Pubmed ID: 25170345
22. Onoda, A., Hosoya, O., Sano, K., Kiyama, K., Kimura, H., Kawano, S., Furuta, R., Miyaji, M., Tsutsui, K., and Tsutsui, K. M.
Nuclear dynamics of topoisomerase IIbeta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
Nucleic Acids Res 42, 9005-9020, 2014
Pubmed ID: 25034690
23. Nakayama, T., Mihara, K., Kawata, J., Kimura, H., and Saitoh, H.
Adhesion of suspension cells on a coverslip in serum-free conditions
Anal Biochem 466, 1-3, 2014
Pubmed ID: 25086365
 [領域内共同研究:斉藤(寿)・木村]
24. Maejima, T., Inoue, T., Kanki, Y., Kohro, T., Li, G., Ohta, Y., Kimura, H., Kobayashi, M., Taguchi, A., Tsutsumi, S., Iwanari, H., Yamamoto, S., Aruga, H., Dong, S., Stevens, J. F., Poh, H. M., Yamamoto, K., Kawamura, T., Mimura, I., Suehiro, J., Sugiyama, A., Kaneki, K., Shibata, H., Yoshinaka, Y., Doi, T., Asanuma, A., Tanabe, S., Tanaka, T., Minami, T., Hamakubo, T., Sakai, J., Nozaki, N., Aburatani, H., Nangaku, M., Ruan, X., Tanabe, H., Ruan, Y., Ihara, S., Endo, A., Kodama, T., and Wada, Y.
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells
PLoS One 9, e96005, 2014
Pubmed ID: 24797675
25. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., and Gurdon, J. B.
Hierarchical molecular events driven by oocyte-specific factors lead to rapid and extensive reprogramming
Mol Cell 55, 524-536, 2014
Pubmed ID: 25066233
26. Hori, T., Shang, W. H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W. C., and Fukagawa, T.
Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly
Dev Cell 29, 740-749, 2014
Pubmed ID: 24960696
 [領域内共同研究:堀・木村]
27. Hirose, T., Virnicchi, G., Tanigawa, A., Naganuma, T., Li, R., Kimura, H., Yokoi, T., Nakagawa, S., Benard, M., Fox, A. H., and Pierron, G.
NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
Mol Biol Cell 25, 169-183, 2014
Pubmed ID: 24173718
28. Hayashi-Takanaka, Y., Stasevich, T. J., Kurumizaka, H., Nozaki, N., and Kimura, H.
Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging
PLoS One 9, e106271, 2014
Pubmed ID: 25184362 責任著者
 [領域内共同研究:木村・胡桃坂]
29. Hayashi, A., Yamauchi, N., Shibahara, J., Kimura, H., Morikawa, T., Ishikawa, S., Nagae, G., Nishi, A., Sakamoto, Y., Kokudo, N., Aburatani, H., and Fukayama, M.
Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior
PLoS One 9, e91330, 2014
Pubmed ID: 24614346
30. Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C. Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B. C., and Morohashi, K.
Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1
Nat Commun 5, 3634, 2014
Pubmed ID: 24727981
 [領域内共同研究:木村・大川]
31 Sato, Y., Mukai, M., Ueda, J., Muraki, M., Stasevich, T. J., Horikoshi, N., Kujirai, T., Kita, H., Kimura, T., Hira, S., Okada, Y., Hayashi-Takanaka, Y., Obuse, C., Kurumizaka, H., Kawahara, A., Yamagata, K., Nozaki, N., and Kimura, H.
Genetically encoded system to track histone modification in vivo
Sci Rep 3, 2436, 2013
Pubmed ID: 23942372 責任著者
 [領域内共同研究:木村・山縣・胡桃坂・小布施]
32. Sadaie, M., Salama, R., Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R., Narita, M., Perez-Mancera, P. A., Bennett, D. C., Chong, H., Kimura, H., and Narita, M.
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
Genes Dev 27, 1800-1808, 2013
Pubmed ID: 23964094
33. Muramatsu, D., Singh, P. B., Kimura, H., Tachibana, M., and Shinkai, Y.
Pericentric heterochromatin generated by HP1 protein interaction-defective histone methyltransferase Suv39h1
J Biol Chem 288, 25285-25296, 2013
Pubmed ID: 23836914
34. Kuroki, S., Akiyoshi, M., Tokura, M., Miyachi, H., Nakai, Y., Kimura, H., Shinkai, Y., and Tachibana, M.
JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice
Biol Reprod 89, 93, 2013
Pubmed ID: 24006281
35. Inoue, D., Kitaura, J., Togami, K., Nishimura, K., Enomoto, Y., Uchida, T., Kagiyama, Y., Kawabata, K. C., Nakahara, F., Izawa, K., Oki, T., Maehara, A., Isobe, M., Tsuchiya, A., Harada, Y., Harada, H., Ochiya, T., Aburatani, H., Kimura, H., Thol, F., Heuser, M., Levine, R. L., Abdel-Wahab, O., and Kitamura, T.
Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations
J Clin Invest 123, 4627-4640, 2013
Pubmed ID: 24216483
36. Horikoshi, N., Sato, K., Shimada, K., Arimura, Y., Osakabe, A., Tachiwana, H., Hayashi-Takanaka, Y., Iwasaki, W., Kagawa, W., Harata, M., Kimura, H., and Kurumizaka, H.
Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2
Acta Crystallogr D Biol Crystallogr 69, 2431-2439, 2013
Pubmed ID: 24311584
 [領域内共同研究:木村・胡桃坂]
37. Eberhart, A., Feodorova, Y., Song, C., Wanner, G., Kiseleva, E., Furukawa, T., Kimura, H., Schotta, G., Leonhardt, H., Joffe, B., and Solovei, I.
Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina
Chromosome Res 21, 535-554, 2013
Pubmed ID: 23996328
38. Dinant, C., Ampatziadis-Michailidis, G., Lans, H., Tresini, M., Lagarou, A., Grosbart, M., Theil, A. F., van Cappellen, W. A., Kimura, H., Bartek, J., Fousteri, M., Houtsmuller, A. B., Vermeulen, W., and Marteijn, J. A.
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage
Mol Cell 51, 469-479, 2013
Pubmed ID: 23973375
39. Arimura, Y., Kimura, H., Oda, T., Sato, K., Osakabe, A., Tachiwana, H., Sato, Y., Kinugasa, Y., Ikura, T., Sugiyama, M., Sato, M., and Kurumizaka, H.
Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin
Sci Rep 3, 3510, 2013
Pubmed ID: 24336483
 [領域内共同研究:木村・小田・杉山・胡桃坂]
40. Abd Al Kader, L., Oka, T., Takata, K., Sun, X., Sato, H., Murakami, I., Toji, T., Manabe, A., Kimura, H., and Yoshino, T.
In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2
Virchows Arch 463, 697-711, 2013
Pubmed ID: 23948956

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